Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16045372 | 0.81 | KDM5A (0.51) | KDM5APLATHPGDLMNAPPARG | |
| SCHEMBL16046982 | 0.76 | KDM5A (0.48) | KDM5AHPGDLMNAPPARGNCOR2 | |
| SCHEMBL20427614 | 0.74 | KDM5A (0.34) | KDM5AKDM4D | |
| SCHEMBL16047451 | 0.72 | KDM4D (0.44) | KDM5APLATHPGDKDM4EALDH1A1 | |
| SCHEMBL16048098 | 0.66 | KDM4D (0.43) | KDM5APLATHPGDLMNAKDM4E | |
| SCHEMBL16077819 | 0.66 | HPGD (0.47) | KDM5APLATHPGDLMNAKDM4E | |
| SCHEMBL9211760 | 0.65 | KDM4D (0.42) | KDM5APLATHPGDLMNAKDM4E | |
| SCHEMBL16077828 | 0.59 | KDM4E (0.59) | PLATHPGDKDM4EALDH1A1KDM4D | |
| SCHEMBL16046782 | 0.59 | KDM5A (0.57) | KDM5APLATHPGDLMNAKDM4E | |
| SCHEMBL23635357 | 0.59 | KDM5A (0.42) | KDM5APLATHPGDLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035801-B2 | Pyrazolo compounds and uses thereof | GENENTECH, INC. (US) | 2018-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035801-B2 | Pyrazolo compounds and uses thereof | KDM5A, KDM5C, KDM5B | KDM5A 1/4885PLAT 4107/4885HPGD 1427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.