Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16661015 | 0.89 | DGAT1 (0.56) | NR1H2NR1H3DGAT1ADORA3ADORA2A | |
| SCHEMBL16661188 | 0.88 | NR1H2 (0.41) | NR1H2NR1H3DGAT1ADORA3ADORA2A | |
| SCHEMBL16660978 | 0.75 | DGAT1 (0.74) | NR1H2NR1H3DGAT1AHRTP53 | |
| SCHEMBL21064877 | 0.74 | DGAT1 (0.56) | NR1H2NR1H3DGAT1AHRTP53 | |
| SCHEMBL16660852 | 0.73 | DGAT1 (0.50) | NR1H2NR1H3DGAT1AHRTP53 | |
| SCHEMBL16660890 | 0.73 | DGAT1 (0.80) | DGAT1 | |
| SCHEMBL16787869 | 0.72 | DGAT1 (0.62) | NR1H2NR1H3DGAT1ADORA2A | |
| SCHEMBL16660877 | 0.72 | DGAT1 (0.61) | DGAT1MAPT | |
| SCHEMBL16661342 | 0.67 | DGAT1 (0.44) | NR1H2NR1H3DGAT1AHRTP53 | |
| SCHEMBL16660927 | 0.66 | DGAT1 (0.53) | NR1H2NR1H3DGAT1AHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2862856-B1 | IMIDAZOLE AND TRIAZOLE COMPOUNDS AS DGAT-1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2018-08-01 | — | — | EP | disclosed |