Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | CDC14B | O60729 | 1/20 | 0.34 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11891531 | 0.79 | RXFP1 (0.40) | RXFP1CDC14BCDC14ASLC22A12PKM | |
| SCHEMBL31722798 | 0.79 | RXFP1 (0.40) | RXFP1CDC14BCDC14ASLC22A12PKM | |
| SCHEMBL19284577 | 0.79 | IDO1 (0.38) | KCNJ11RXFP1CDC14BCDC14APKM | |
| SCHEMBL17711245 | 0.77 | KDM4E (0.54) | KCNJ11NPSR1KDM4EMEN1MAPT | |
| SCHEMBL15538116 | 0.76 | RXFP1 (0.42) | KCNJ11RXFP1CDC14BCDC14ASLC22A12 | |
| SCHEMBL16849211 | 0.74 | HSD11B1 (0.33) | KCNJ11SLC22A12NPSR1KDM4EMEN1 | |
| SCHEMBL28905011 | 0.73 | PKM (0.37) | RXFP1SLC22A12PKMNPSR1KDM4E | |
| SCHEMBL17716642 | 0.73 | KDM4E (0.40) | KCNJ11RXFP1CDC14BCDC14APKM | |
| SCHEMBL28805148 | 0.72 | RXFP1 (0.46) | KCNJ11RXFP1SLC22A12PKMNPSR1 | |
| SCHEMBL30710586 | 0.71 | RXFP1 (0.48) | RXFP1PKMKDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3354651-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF ROR-GAMMA-T | Janssen Pharmaceutica N.V. (BE) | 2018-08-01 | — | — | EP | disclosed |