Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 15/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TPO | P07202 | 1/20 | 0.34 |
| ▸ | EPX | P11678 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20429890 | 0.92 | MPO (0.50) | MPOSMN1; SMN2TP53LRRK2ALDH1A1 | |
| SCHEMBL19282301 | 0.87 | MPO (0.51) | MPOTPOEPX | |
| SCHEMBL19282210 | 0.87 | MPO (0.67) | MPOTP53TPOEPX | |
| SCHEMBL19282302 | 0.84 | MPO (0.49) | MPOTPOEPX | |
| SCHEMBL20429915 | 0.84 | MPO (0.46) | MPOTPOEPX | |
| SCHEMBL19297858 | 0.82 | MPO (0.49) | MPOTPOEPX | |
| SCHEMBL19282221 | 0.81 | MPO (0.70) | MPOSMN1; SMN2ALDH1A1MEN1NPC1 | |
| SCHEMBL19282287 | 0.81 | MPO (0.50) | MPOTPOEPX | |
| SCHEMBL19282201 | 0.81 | MPO (0.56) | MPOSMN1; SMN2TP53ALDH1A1KDM4E | |
| SCHEMBL19282270 | 0.81 | MPO (0.66) | MPOSMN1; SMN2MEN1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191486-B1 | THIOETHER TRIAZOLOPYRIDINE AND TRIAZOLOPYRMIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL MYERS SQUIBB CO (US) | 2018-08-01 | — | — | EP | disclosed |