Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2045727 | 0.81 | KDM4C (0.53) | KDM4CTDP1POLBL3MBTL1APEX1 | |
| SCHEMBL2628993 | 0.78 | L3MBTL1 (0.53) | KDM4CTDP1POLBL3MBTL1APEX1 | |
| SCHEMBL2039662 | 0.76 | L3MBTL1 (0.47) | KDM4CTDP1POLBL3MBTL1APEX1 | |
| SCHEMBL2036931 | 0.76 | HPGD (0.55) | TDP1POLBL3MBTL1APEX1RECQL | |
| SCHEMBL2037416 | 0.75 | L3MBTL1 (0.46) | KDM4CTDP1POLBL3MBTL1APEX1 | |
| SCHEMBL2037378 | 0.71 | HPGD (0.53) | L3MBTL1ALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL29135322 | 0.71 | TDP1 (0.51) | KDM4CTDP1POLBL3MBTL1APEX1 | |
| SCHEMBL7624260 | 0.71 | TDP1 (0.51) | KDM4CTDP1POLBL3MBTL1APEX1 | |
| SCHEMBL7624256 | 0.71 | TDP1 (0.51) | KDM4CTDP1POLBL3MBTL1APEX1 | |
| SCHEMBL7624265 | 0.71 | TDP1 (0.51) | KDM4CTDP1POLBL3MBTL1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |