Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7624260 | 1.00 | TDP1 (0.51) | TDP1L3MBTL1POLBAPEX1RECQL | |
| SCHEMBL7624265 | 1.00 | TDP1 (0.51) | TDP1L3MBTL1POLBAPEX1RECQL | |
| SCHEMBL29135322 | 0.81 | TDP1 (0.51) | TDP1L3MBTL1POLBAPEX1RECQL | |
| SCHEMBL8561761 | 0.74 | KMT2A (0.46) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL6365294 | 0.74 | CA12 (0.55) | TDP1L3MBTL1POLBAPEX1RECQL | |
| SCHEMBL14171596 | 0.73 | CA12 (0.51) | TDP1L3MBTL1POLBAPEX1RECQL | |
| SCHEMBL8563081 | 0.73 | KDM4E (0.39) | ALDH1A1KDM4ECYP2C19 | |
| SCHEMBL8563078 | 0.73 | KDM4E (0.39) | ALDH1A1KDM4ECYP2C19 | |
| Bromide SCHEMBL7614674 | 0.72 | L3MBTL1 (0.46) | TDP1L3MBTL1POLBAPEX1RECQL | |
| Bromide SCHEMBL7614677 | 0.72 | L3MBTL1 (0.46) | TDP1L3MBTL1POLBAPEX1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620225-B1 | Cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2002-11-13 | — | — | EP | disclosed |
| CN-1046524-C | Cephalosporin derivatives | HOFFMANN LA ROCHE (CH) | 1999-11-17 | — | — | CN | disclosed |
| US-5523400-A | 3-(PYRROLIDIN-3-YLIDENE=CH-),7-((2-AMINOTHIAZOL-4-YL)HYDROX -IMINOACETYLAMINO-)-3-CEPHEM DERIVATIVES; BROAD SPECTRUM ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1996-06-04 | — | — | US | disclosed |
| CN-1105365-A | Cephalosporin derivatives | HOFFMANN LA ROCHE (CH) | 1995-07-19 | — | — | CN | disclosed |
| EP-0620225-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-10-19 | — | — | EP | disclosed |