Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.42 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 18/20 | 0.41 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834916 | 0.95 | TRPC4 (0.45) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL21499680 | 0.92 | P2RX3 (0.39) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL21316297 | 0.92 | TRPC4 (0.42) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL19505572 | 0.91 | TRPC4 (0.47) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL19374704 | 0.91 | TRPC4 (0.42) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL19375398 | 0.90 | P2RX3 (0.38) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL19375568 | 0.90 | TRPC4 (0.43) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL20432432 | 0.89 | PDE5A (0.37) | TRPC5P2RX3 | |
| SCHEMBL21499648 | 0.88 | TRPC4 (0.40) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL19505503 | 0.88 | TRPC4 (0.39) | TRPC4TRPC5KCNH2P2RX3TRPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B3 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2018-08-01 | — | — | EP | disclosed |