Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | RGS4 | P49798 | 2/20 | 0.35 |
| ▸ | RGS8 | P57771 | 2/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21499648 | 0.91 | TRPC4 (0.40) | PDE5AP2RX3TRPC5ADORA3 | |
| SCHEMBL19375398 | 0.90 | P2RX3 (0.38) | PDE5AP2RX3TSHRTRPC5CYP1A2 | |
| SCHEMBL21499680 | 0.90 | P2RX3 (0.39) | P2RX3TSHRTRPC5CYP1A2CYP3A4 | |
| SCHEMBL20432022 | 0.89 | TRPC4 (0.42) | P2RX3TRPC5 | |
| SCHEMBL18833918 | 0.86 | P2RX3 (0.35) | PDE5AP2RX3TSHRTRPC5CYP1A2 | |
| SCHEMBL19375436 | 0.86 | P2RX7 (0.35) | PDE5AP2RX3TSHRTRPC5ADORA3 | |
| SCHEMBL19375181 | 0.85 | TRPC5 (0.41) | P2RX3TSHRTRPC5CYP1A2CYP3A4 | |
| SCHEMBL18835230 | 0.85 | ALDH1A1 (0.41) | P2RX3TSHRCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL19375600 | 0.84 | P2RX3 (0.34) | PDE5AP2RX3TSHRTRPC5 | |
| SCHEMBL18834916 | 0.83 | TRPC4 (0.45) | P2RX3TRPC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B3 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2018-08-01 | — | — | EP | disclosed |