Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | TLR2 | O60603 | 2/20 | 0.46 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | GNPAT | O15228 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | CPA2 | P48052 | 1/20 | 0.40 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.40 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12749404 | 1.00 | SIRT6 (0.58) | SIRT6SIRT1CA1CA2FOLH1 | |
| SCHEMBL20435058 | 1.00 | SIRT6 (0.58) | SIRT6SIRT1CA1CA2FOLH1 | |
| SCHEMBL11896083 | 0.90 | SIRT6 (0.56) | SIRT6SIRT1CA1CA2FOLH1 | |
| SCHEMBL726302 | 0.90 | SIRT6 (0.56) | SIRT6SIRT1CA1CA2FOLH1 | |
| Hydrochloric Acid SCHEMBL7347980 | 0.89 | SIRT6 (0.55) | SIRT6SIRT1CA1CA2FOLH1 | |
| SCHEMBL20530 | 0.86 | FOLH1 (0.62) | SIRT6SIRT1CA1CA2FOLH1 | |
| SCHEMBL919220 | 0.86 | FOLH1 (0.62) | SIRT6SIRT1CA1CA2FOLH1 | |
| SCHEMBL20529 | 0.86 | FOLH1 (0.62) | SIRT6SIRT1CA1CA2FOLH1 | |
| SCHEMBL16771271 | 0.86 | FOLH1 (0.49) | SIRT6SIRT1CA1CA2FOLH1 | |
| SCHEMBL7294147 | 0.85 | SIRT6 (0.55) | SIRT6SIRT1CA1CA2FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018138591-A1 | CALICHEAMICIN DERIVATIVES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER INC. (US) | 2018-08-02 | — | — | WO | disclosed |