Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 12/20 | 0.41 |
| ▸ | KLK1 | P06870 | 2/20 | 0.41 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825716 | 0.85 | KLKB1 (0.46) | HDAC1HDAC2KLKB1IRAK4ALDH1A1 | |
| SCHEMBL20416533 | 0.85 | HDAC1 (0.39) | HDAC1HDAC2KLKB1TAS2R8IRAK4 | |
| SCHEMBL20401337 | 0.78 | FFAR1 (0.51) | HDAC1HDAC2KLKB1TAS2R8IRAK4 | |
| SCHEMBL2328430 | 0.71 | IRAK4 (0.39) | HDAC1HDAC2KLKB1IRAK4 | |
| SCHEMBL17820696 | 0.71 | CXCR4 (0.47) | ALDH1A1 | |
| SCHEMBL2328427 | 0.70 | IRAK4 (0.39) | IRAK4GRM2 | |
| SCHEMBL1054149 | 0.70 | NPSR1 (0.44) | IRAK4ALDH1A1CYP1A2 | |
| SCHEMBL30952862 | 0.70 | NPSR1 (0.44) | IRAK4ALDH1A1CYP1A2 | |
| SCHEMBL12432224 | 0.70 | IRAK4 (0.49) | IRAK4KCNH2ALDH1A1CYP1A2 | |
| SCHEMBL6938242 | 0.70 | CREBBP (0.56) | HDAC1TAS2R8ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180215730-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES, INC. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215730-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ADORA2A, ADORA2B, ADORA1 | HDAC1 3195/4885HDAC2 2394/4885KLKB1 1782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.