Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 8/20 | 0.35 |
| ▸ | CTSS | P25774 | 7/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20417166 | 0.87 | HRH4 (0.41) | KCNH2HRH4KDM4EALDH1A1GRIN2D | |
| SCHEMBL15259719 | 0.87 | HRH4 (0.47) | KCNH2HRH4KDM4EALDH1A1GRIN2D | |
| SCHEMBL20436608 | 0.80 | KDM4E (0.34) | KCNH2HRH4KDM4EALDH1A1GRIN2D | |
| SCHEMBL2522650 | 0.79 | KCNH2 (0.67) | KCNH2KDM4EALDH1A1GRIN2DGRIN3B | |
| SCHEMBL20436537 | 0.79 | CACNA1C (0.45) | KCNH2HRH4KDM4EALDH1A1CXCR4 | |
| SCHEMBL15314267 | 0.79 | ALDH1A1 (0.40) | HRH4KDM4EALDH1A1GRIN2DGRIN3B | |
| SCHEMBL17258436 | 0.79 | HRH4 (0.44) | KCNH2HRH4KDM4EALDH1A1GRIN2D | |
| SCHEMBL17768583 | 0.79 | HRH4 (0.40) | KCNH2HRH4KDM4EALDH1A1GRIN2D | |
| SCHEMBL30400479 | 0.78 | KDM4E (0.37) | KCNH2HRH4KDM4EALDH1A1GRIN2D | |
| SCHEMBL20436460 | 0.78 | KDM4E (0.37) | KCNH2HRH4KDM4EALDH1A1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180215730-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES, INC. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215730-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ADORA2A, ADORA2B, ADORA1 | KCNH2 4207/4885HRH4 787/4885KDM4E 3131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.