Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20417081 | 0.99 | CYP19A1 (0.39) | LRRK2CYP19A1HDAC2HDAC8HDAC6 | |
| SCHEMBL20436556 | 0.89 | ADORA2A (0.46) | LRRK2ADORA2BADORA1ADORA2AUSP2 | |
| SCHEMBL20416648 | 0.88 | ADORA2A (0.46) | LRRK2ADORA2BADORA1ADORA2AUSP2 | |
| SCHEMBL20401302 | 0.87 | PDE4D (0.47) | CYP19A1HDAC2HDAC8HDAC6KLKB1 | |
| SCHEMBL20436555 | 0.86 | ADORA2A (0.46) | LRRK2ADORA2BADORA1ADORA2A | |
| SCHEMBL30401312 | 0.84 | NOTUM (0.44) | LRRK2CYP19A1HDAC2HDAC8HDAC6 | |
| SCHEMBL20416863 | 0.84 | NOTUM (0.44) | LRRK2CYP19A1HDAC2HDAC8HDAC6 | |
| SCHEMBL20436698 | 0.84 | KLKB1 (0.38) | LRRK2CYP19A1HDAC2HDAC8HDAC6 | |
| SCHEMBL20436700 | 0.84 | KLKB1 (0.38) | LRRK2CYP19A1HDAC2HDAC8HDAC6 | |
| SCHEMBL20416723 | 0.84 | CYP19A1 (0.43) | CYP19A1HDAC2HDAC8HDAC6KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180215730-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES, INC. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215730-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ADORA2A, ADORA2B, ADORA1 | LRRK2 2878/4885CYP19A1 1735/4885HDAC2 2394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.