Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | OGA | O60502 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19987494 | 0.88 | HSD17B10 (0.51) | HSD17B10SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL14483866 | 0.84 | PPARA (0.36) | HSD17B10SMN1; SMN2NPC1RAB9AOGA | |
| SCHEMBL21439946 | 0.84 | SMN1; SMN2 (0.51) | HSD17B10SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL31359263 | 0.80 | SMN1; SMN2 (0.53) | HSD17B10SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL85424 | 0.80 | SMN1; SMN2 (0.53) | HSD17B10SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL21239914 | 0.78 | SMN1; SMN2 (0.45) | HSD17B10SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL30644691 | 0.78 | SMN1; SMN2 (0.50) | HSD17B10SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL17541679 | 0.78 | SMN1; SMN2 (0.50) | HSD17B10SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL17541632 | 0.78 | SMN1; SMN2 (0.54) | HSD17B10SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL24512882 | 0.77 | HSD17B10 (0.39) | HSD17B10SMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10683288-B2 | Epothilone B and dictyostatin analogs, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-06-16 | — | — | US | disclosed |
| US-20180215748-A1 | EPOTHILONE B AND DICTYOSTATIN ANALOGS, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10683288-B2 | Epothilone B and dictyostatin analogs, their preparation and use | DHPS, EPOR, THPO | HSD17B10 830/4885SMN1; SMN2 4152/4885NPC1 3505/4885 |
| US-20180215748-A1 | EPOTHILONE B AND DICTYOSTATIN ANALOGS, THEIR PREPARATION AND USE | DHPS, EPOR, THPO | HSD17B10 830/4885SMN1; SMN2 4152/4885NPC1 3505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.