Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.41 |
| ▸ | GABRE | P78334 | 2/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 8/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29819516 | 0.88 | KIF11 (0.47) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL1707718 | 0.88 | KIF11 (0.47) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL15434247 | 0.85 | KIF11 (0.45) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL17299583 | 0.84 | KIF11 (0.45) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL20437834 | 0.83 | PARP1 (0.43) | BCHEGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL20437697 | 0.82 | KIF11 (0.43) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL19383173 | 0.81 | KIF11 (0.58) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL24519188 | 0.79 | KIF11 (0.53) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL16940920 | 0.78 | KIF11 (0.44) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL19382779 | 0.78 | CDK4 (0.45) | KIF11BCHEGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10964894-B2 | Carbazole derivatives | MERCK PATENT GMBH (DE) | 2021-03-30 | — | — | US | disclosed |
| US-20190348616-A1 | CARBAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-11-14 | — | — | US | disclosed |
| WO-2018138039-A1 | CARBAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190348616-A1 | CARBAZOLE DERIVATIVES | CYP2E1, CYP3A4, CYP2C19 | KIF11 2810/4885BCHE 1030/4885GABRP 2077/4885 |
| US-10964894-B2 | Carbazole derivatives | CYP2E1, CYP3A4, CYP2C19 | KIF11 2810/4885BCHE 1030/4885GABRP 2077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.