Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 4/20 | 0.37 |
| ▸ | CCND1 | P24385 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2603644 | 0.88 | KIF11 (0.42) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL17299618 | 0.85 | KIF11 (0.43) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL20438139 | 0.84 | PARP1 (0.41) | BCHEGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL20437695 | 0.82 | KIF11 (0.45) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL20327438 | 0.81 | BCHE (0.40) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL19382781 | 0.80 | KIF11 (0.50) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL17050080 | 0.80 | KIF11 (0.46) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL20327743 | 0.79 | TDO2 (0.42) | KIF11BCHEGABRPGABRDGABRA1 | |
| SCHEMBL20437689 | 0.78 | AHR (0.41) | KIF11BCHE | |
| SCHEMBL18688079 | 0.78 | GABRP (0.42) | KIF11BCHEGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10964894-B2 | Carbazole derivatives | MERCK PATENT GMBH (DE) | 2021-03-30 | — | — | US | disclosed |
| US-20190348616-A1 | CARBAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-11-14 | — | — | US | disclosed |
| WO-2018138039-A1 | CARBAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190348616-A1 | CARBAZOLE DERIVATIVES | CYP2E1, CYP3A4, CYP2C19 | KIF11 2810/4885BCHE 1030/4885GABRP 2077/4885 |
| US-10964894-B2 | Carbazole derivatives | CYP2E1, CYP3A4, CYP2C19 | KIF11 2810/4885BCHE 1030/4885GABRP 2077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.