Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2041827 | 0.91 | AAK1 (0.47) | ACSS2GAAS1PR1RAB9A | |
| SCHEMBL2041269 | 0.89 | GAA (0.44) | ACSS2GAAS1PR1MAPTNPSR1 | |
| SCHEMBL2038872 | 0.88 | GAA (0.41) | ACSS2GAAS1PR1MAPTNPSR1 | |
| SCHEMBL2039832 | 0.88 | ACSS2 (0.49) | ACSS2GAAS1PR1 | |
| SCHEMBL2042201 | 0.86 | NPSR1 (0.55) | GAAMAPTKDM4EHPGDRAB9A | |
| SCHEMBL2042553 | 0.86 | ACSS2 (0.51) | ACSS2S1PR1 | |
| SCHEMBL2039680 | 0.82 | AAK1 (0.46) | ACSS2GAAS1PR1MAPTKDM4E | |
| SCHEMBL2043182 | 0.82 | HDAC1 (0.42) | GAAS1PR1MAPTKDM4ERAB9A | |
| SCHEMBL2040393 | 0.80 | S1PR1 (0.47) | GAAS1PR1KDM4EHPGDHTT | |
| SCHEMBL2037490 | 0.77 | TDP1 (0.45) | GAAS1PR1MAPTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |