Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2040172 | 0.90 | ALDH1A1 (0.52) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL2040358 | 0.88 | LMNA (0.60) | NPSR1GAAMAPTHDAC1HDAC6 | |
| SCHEMBL2043288 | 0.88 | GAA (0.58) | GAAMAPTHDAC1HDAC6POLB | |
| SCHEMBL2043795 | 0.86 | ACSS2 (0.49) | NPSR1GAAMAPTHDAC3HDAC4 | |
| SCHEMBL2041269 | 0.85 | GAA (0.44) | NPSR1GAAMAPTHDAC3HDAC4 | |
| SCHEMBL2042632 | 0.85 | HPGD (0.56) | GAAMAPTKDM4ERAB9ACASP7 | |
| SCHEMBL2039832 | 0.84 | ACSS2 (0.49) | GAAALDH1A1 | |
| SCHEMBL2038872 | 0.84 | GAA (0.41) | NPSR1GAAMAPTHDAC3HDAC4 | |
| SCHEMBL2043182 | 0.83 | HDAC1 (0.42) | NPSR1GAAMAPTHDAC3HDAC4 | |
| SCHEMBL2039016 | 0.83 | ALDH1A1 (0.46) | NPSR1GAAHDAC3HDAC1HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |