Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.33 |
| ▸ | RELA | Q04206 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15007521 | 0.92 | DGAT1 (0.38) | DGAT1MTORRPTORMLST8GPR119 | |
| SCHEMBL20216 | 0.92 | DGAT1 (0.38) | DGAT1MTORRPTORMLST8GPR119 | |
| SCHEMBL15007320 | 0.91 | DGAT1 (0.38) | DGAT1MTORRPTORMLST8GPR119 | |
| SCHEMBL20609 | 0.91 | DGAT1 (0.37) | DGAT1MTORRPTORMLST8GPR119 | |
| SCHEMBL20539 | 0.87 | DGAT1 (0.35) | DGAT1MTORRPTORMLST8GPR119 | |
| SCHEMBL20981 | 0.86 | DGAT1 (0.39) | DGAT1MTORRPTORMLST8GPR119 | |
| SCHEMBL21331 | 0.86 | DGAT1 (0.42) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL7874673 | 0.85 | DGAT1 (0.41) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL7878571 | 0.84 | DGAT1 (0.36) | DGAT1MTORRPTORMLST8KDM4E | |
| SCHEMBL7882528 | 0.84 | DGAT1 (0.42) | DGAT1MTORRPTORMLST8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027236-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |