Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 7/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874755 | 0.92 | DGAT1 (0.40) | DGAT1MTORRPTORMLST8TTK | |
| SCHEMBL2679696 | 0.92 | DGAT1 (0.40) | DGAT1MTORRPTORMLST8TTK | |
| SCHEMBL2679702 | 0.92 | DGAT1 (0.40) | DGAT1MTORRPTORMLST8TTK | |
| SCHEMBL7886478 | 0.92 | DGAT1 (0.38) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL7882528 | 0.90 | DGAT1 (0.42) | DGAT1MTORRPTORMLST8JAK1 | |
| SCHEMBL2679979 | 0.85 | DGAT1 (0.39) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL2679976 | 0.85 | DGAT1 (0.39) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL20438 | 0.85 | DGAT1 (0.38) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL21331 | 0.85 | DGAT1 (0.42) | DGAT1MTORRPTORMLST8JAK1 | |
| SCHEMBL2727145 | 0.84 | DGAT1 (0.42) | DGAT1MTORRPTORMLST8JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |