Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 12/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | HIPK2 | Q9H2X6 | 5/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.44 |
| ▸ | CLK2 | P49760 | 4/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.44 |
| ▸ | PIM1 | P11309 | 4/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.44 |
| ▸ | PAK4 | O96013 | 3/20 | 0.44 |
| ▸ | PRKX | P51817 | 3/20 | 0.44 |
| ▸ | MELK | Q14680 | 3/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | PRKACA | P17612 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18397914 | 0.88 | LOXL2 (0.54) | LOXL2CDC7MAOBHIPK2DAPK3 | |
| SCHEMBL20438090 | 0.87 | LOXL2 (0.64) | LOXL2MAOBHDAC3HDAC4HDAC1 | |
| SCHEMBL20438089 | 0.87 | LOXL2 (0.43) | LOXL2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL20438087 | 0.85 | LOXL2 (0.48) | LOXL2DYRK1AGSK3BPDPK1 | |
| SCHEMBL20438091 | 0.85 | LOXL2 (0.48) | LOXL2CDC7MAOBPDPK1 | |
| SCHEMBL20438076 | 0.81 | BCHE (0.47) | HDAC1 | |
| SCHEMBL20438084 | 0.81 | BCHE (0.46) | LOXL2PDPK1AKT1 | |
| SCHEMBL18664515 | 0.80 | MEN1 (0.55) | CDC7HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20438101 | 0.80 | P2RY14 (0.43) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL18397889 | 0.80 | LOXL2 (0.70) | LOXL2CDC7HIPK2DAPK3CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180215727-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. | 2018-08-02 | — | — | US | disclosed |
| US-20180215727-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215727-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | LOXL2, LOXL1, LOX | LOXL2 1/4885CDC7 4449/4885MAOB 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.