Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meclizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | CNR1 | P21554 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | GHSR | Q92847 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meclizine SCHEMBL755731 | 1.00 | KCNH2 (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL4649 | 1.00 | KCNH2 (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL4650 | 1.00 | KCNH2 (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL29374995 | 1.00 | KCNH2 (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL41366 | 0.99 | LMNA (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL2193375 | 0.99 | LMNA (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL743819 | 0.99 | LMNA (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL145896 | 0.99 | KCNH2 (0.98) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL11659258 | 0.98 | KCNH2 (0.95) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL743004 | 0.98 | LMNA (0.98) | KCNH2CYP3A4ADORA3CNR1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2059 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11944618-B2 | Subcutaneous delivery of polymer conjugates of therapeutic agents | SERINA THERAPEUTICS, INC. (US) | 2024-04-02 | — | — | US | claimed |
| US-20240091760-A1 | METHOD FOR TREATING OR REGENERATING METAL CATALYST AND APPLICATION | BEIJING SINGLE ATOM SITE CATALYSIS TECHNOLOGY CO., LTD (CN) | 2024-03-21 | — | — | US | claimed |
| WO-2024015331-A1 | THERAPEUTIC AND DIAGNOSTIC METHODS FOR MULTIPLE SCLEROSIS | GENENTECH, INC. (US) | 2024-01-18 | — | — | WO | claimed |
| US-20230009076-A1 | POLYOXAZOLINE-DRUG CONJUGATES WITH NOVEL PHARMACOKINETIC PROPERTIES | SERINA THERAPEUTICS, INC. (US) | 2023-01-12 | — | — | US | claimed |
| EP-3990026-A1 | POLYOXAZOLINE-DRUG CONJUGATES WITH NOVEL PHARMACOKINETIC PROPERTIES | Serina Therapeutics, Inc. (US) | 2022-05-04 | — | — | EP | claimed |
| CN-110713937-B | Method for improving content of boswellin (a secondary metabolite of PA) of Eremorhedi sinensis-endophytic fungi strain | 兰州大学 | 2022-02-01 | — | — | CN | claimed |
| WO-2020264505-A1 | POLYOXAZOLINE-DRUG CONJUGATES WITH NOVEL PHARMACOKINETIC PROPERTIES | SERINA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | claimed |
| WO-2020231948-A1 | DIAGNOSIS OF MULTIPLE SCLEROSIS IN HUMAN AND ANIMAL SUBJECTS | OP-T LLC (US) | 2020-11-19 | — | — | WO | claimed |
| US-20200147076-A1 | PARENTERAL FORMULATIONS OF LIPOPHILIC PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME | PLATFORM BRIGHTWORKS TWO, LTD. (US) | 2020-05-14 | — | — | US | claimed |
| US-20200093816-A1 | SUBCUTANEOUS DELIVERY OF POLYMER CONJUGATES OF THERAPEUTICS AGENTS | SERINA THERAPEUTICS (AL), INC. | 2020-03-26 | — | — | US | claimed |
| US-5021349-A | Culture medium containing human albumin, process for the preparation of an injectable product from this medium, product obtained and its use, and composition obtained | Foundation Centre National de Transfusion Sanguine (FR) | 1991-06-04 | — | — | US | claimed |
| EP-0200678-B1 | METHOD FOR GLUEING SURFACES WITH A CURABLE EPOXY RESIN COMPOSITION | CIBA-GEIGY AG (CH) | 1990-09-12 | — | — | EP | claimed |
| EP-0116399-B1 | DITHIOPHOSPHORUS/AMINE SALTS AND AQUEOUS COMPOSITIONS CONTAINING SAME | The Lubrizol Corporation (US) | 1990-03-14 | — | — | EP | claimed |
| EP-0280183-A1 | Method for preparing electrically conductive elastic products | BASF Aktiengesellschaft (DE) | 1988-08-31 | — | — | EP | claimed |
| US-4735736-A | ETHYLENE POLYMERS GRAFTED WITH MALEIC ANHYDRIDE, TREATED WITH POLYAMINE | EXXON CHEMICAL PATENTS INC. (US) | 1988-04-05 | — | — | US | claimed |
| EP-0260952-A2 | A process for the preparation of pigments | COOKSON GROUP plc (GB) | 1988-03-23 | — | — | EP | claimed |
| US-4684713-A | Hydrocarbon terminated polyamide resin and process for producing the same | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1987-08-04 | — | — | US | claimed |
| US-4483798-A | Polyaddition products containing uretidione groups and process for their preparation | CHEMISCHE WERKE HULS AKTIENGESELLSCHAFT (DE) | 1984-11-20 | — | — | US | claimed |
| EP-0116399-A2 | Dithiophosphorus/amine salts and aqueous compositions containing same | The Lubrizol Corporation (US) | 1984-08-22 | — | — | EP | claimed |
| US-4371640-A | A THERMOPLASTIC RESING HAVING SULFONATE GROUPS PARTIALLY NEUTRALIZED BY AN AMINE-TERMINATED POLYOXYALKYLENE GLYCOL AND A TACKIFIER RESIN | EXXON RESEARCH AND ENGINEERING CO. (US) | 1983-02-01 | — | — | US | claimed |