Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meclizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | CNR1 | P21554 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | GHSR | Q92847 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meclizine SCHEMBL755731 | 1.00 | KCNH2 (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL4649 | 1.00 | KCNH2 (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL204393 | 1.00 | KCNH2 (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL29374995 | 1.00 | KCNH2 (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL41366 | 0.99 | LMNA (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL2193375 | 0.99 | LMNA (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL743819 | 0.99 | LMNA (1.00) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL145896 | 0.99 | KCNH2 (0.98) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL11659258 | 0.98 | KCNH2 (0.95) | KCNH2CYP3A4ADORA3CNR1HRH1 | |
| Meclizine SCHEMBL743004 | 0.98 | LMNA (0.98) | KCNH2CYP3A4ADORA3CNR1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 14157 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| EP-4734952-A1 | ORAL TABLET WITH IMPROVED UNIFORMITY OF CONTENT OF ACTIVES | Fertin Pharma A/S (DK) | 2026-05-06 | — | — | EP | claimed |
| EP-4704971-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| US-20260027337-A1 | TRANSDERMAL DRUG DELIVERY DEVICES AND METHODS | MORNINGSIDE VENTURE INVESTMENTS LTD (MC) | 2026-01-29 | — | — | US | claimed |
| US-12534571-B2 | Amphiphilic block copolymer, preparation method thereof and nanomicelle drug-loading system | SHANGHAI BEST-LINK BIOSCIENCE, LLC (CN) | 2026-01-27 | — | — | US | claimed |
| US-12515030-B2 | Transdermal drug delivery devices and methods | MORNINGSIDE VENTURE INVESTMENTS LIMITED (MC) | 2026-01-06 | — | — | US | claimed |
| EP-4658240-A2 | PHARMACEUTICAL COMPOSITIONS FOR NASAL DELIVERY | Therakind Limited (GB) | 2025-12-10 | — | — | EP | claimed |
| US-20250339399-A1 | SUPRAMOLECULAR SELF-ASSEMBLY SYSTEM | BEIJING CREATRON INSTITUTE OF PHARMACEUTICAL RES CO LTD (CN) | 2025-11-06 | — | — | US | claimed |
| US-20250325483-A1 | FLOWPACK WITH COMPOSITION FOR IMPROVED TASTE MASKING OF ACTIVES | FERTIN PHARMA AS (DK) | 2025-10-23 | — | — | US | claimed |
| US-4753800-A | DRUGS ADSORBED ONTO MAGNESIUM ALUMINUM STEARATE | WARNER-LAMBERT COMPANY (US) | 1988-06-28 | — | — | US | claimed |
| US-4729997-A | ANTIEMETICS, ANTIHISTAMINES | NASTECH PHARMACEUTICAL CO., INC. (US) | 1988-03-08 | — | — | US | claimed |
| EP-0201537-A4 | NOVEL USE OF ANTI-NAUSEA AND ANTI-EMETIC PHARMAZEUTICAL AGENTS. | NASTECH PHARM CO (US) | 1987-07-06 | — | — | EP | claimed |
| EP-0126796-B1 | POSITIONING CONTROL AND LOCKING DEVICE FOR A FLUID POWERED ACTUATOR | KOWA SHOJI, LTD. (JP) | 1987-05-13 | — | — | EP | claimed |
| EP-0219458-A2 | Medicament adsorbates and their preparation | WARNER-LAMBERT COMPANY (US) | 1987-04-22 | — | — | EP | claimed |
| US-4649041-A | Magnesium trisilicate suitable for preparation of medicament adsorbates of antinauseants | WARNER-LAMBERT COMPANY (US) | 1987-03-10 | — | — | US | claimed |
| EP-0201537-A1 | NOVEL USE OF ANTI-NAUSEA AND ANTI-EMETIC PHARMAZEUTICAL AGENTS. | NASTECH PHARM CO (US) | 1986-11-20 | — | — | EP | claimed |
| EP-0106167-B1 | APPARATUS FOR AND METHOD OF SECURING THE TAIL OF A ROLL PRODUCT | CROWN ZELLERBACH CORPORATION (US) | 1986-08-13 | — | — | EP | claimed |
| WO-1986002553-A1 | NOVEL METHOD OF ADMINISTERING ANTI-NAUSEA AND ANTI-EMETIC PHARMACEUTICAL AGENTS AND NOVEL DOSAGE FORMS CONTAINING SAME | NASTECH PHARMACEUTICAL COMPANY, INC. (US) | 1986-05-09 | — | — | WO | claimed |
| US-3940485-A | Treatment and pre-treatment of dysmetric dyslexia by improving sequential scanning and ocular fixation abilities and therapeutic compounds | LEVINSON HAROLD N | 1976-02-24 | — | — | US | claimed |