SCHEMBL20439360

SCHEMBL20439360

N[C@@H](COc1cc(OCc2ccccc2)ccc1Br)c1ccc(OC2CCCCO2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 0.37
HRH3 Q9Y5N1 4/20 0.36
CYP2D6 P10635 2/20 0.36
MAOB P27338 3/20 0.35
MAOA P21397 1/20 0.35
CCR5 P51681 1/20 0.34
PDE4A P27815 2/20 0.34
KMT2A Q03164 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
NPC1 O15118 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
NFKB1 P19838 1/20 0.33
GRM5 P41594 1/20 0.33
RAB9A P51151 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
LNPEP Q9UIQ6 1/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20439375 1.00 DHFR (0.37) DHFRHRH3CYP2D6MAOBMAOA
SCHEMBL20425125 0.85 DHFR (0.37) DHFRHRH3CYP2D6MAOBMAOA
SCHEMBL20439319 0.82 SCN4A (0.48) MAOBMAOAKMT2ASMN1; SMN2RAB9A
SCHEMBL5355437 0.82 SCN4A (0.48) MAOBMAOAKMT2ASMN1; SMN2RAB9A
SCHEMBL20439308 0.78 MAOB (0.44) MAOBMAOAKMT2ASMN1; SMN2ALDH1A1
SCHEMBL20439307 0.78 MAOB (0.44) MAOBMAOAKMT2ASMN1; SMN2ALDH1A1
SCHEMBL8601010 0.78 LMNA (0.46) DHFRHRH3CYP2D6MAOBMAOA
SCHEMBL20439362 0.77 TNF (0.34) PDE4AHPGDPDE4BPDE4CPDE4D
SCHEMBL20439359 0.77 TNF (0.34) PDE4AHPGDPDE4BPDE4CPDE4D
SCHEMBL20439314 0.77 SCN4A (0.43) MAOBMAOAKMT2ASMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018138739-A1 NOVEL ANTIESTROGENIC HETEROCYCLIC COMPOUNDS SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) 2018-08-02 WO disclosed