Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KRAS | P01116 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20440035 | 0.89 | ABHD6 (0.49) | HTTHPGDALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL16588035 | 0.84 | HTT (0.76) | HTTHPGDALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL20425782 | 0.81 | RAB9A (0.51) | HTTHPGDALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL20425631 | 0.81 | MAPK1 (0.51) | HTTHPGDALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL23116425 | 0.78 | HPGD (0.42) | HTTHPGDALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL29839323 | 0.78 | HPGD (0.42) | HTTHPGDALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL4518190 | 0.78 | NOTUM (0.63) | ABHD6RAB9ANPC1HSD17B3 | |
| SCHEMBL30575058 | 0.78 | NOTUM (0.63) | ABHD6RAB9ANPC1HSD17B3 | |
| SCHEMBL3808915 | 0.76 | ABHD6 (0.59) | HTTHPGDABHD6RAB9ANPSR1 | |
| SCHEMBL31598007 | 0.76 | ABHD6 (0.59) | HTTHPGDABHD6RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018140876-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. (US) | 2018-08-02 | — | — | WO | disclosed |