Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.41 |
| ▸ | MET | P08581 | 7/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20442999 | 0.85 | ROCK2 (0.46) | BRD4METROCK2KDRFLT3 | |
| SCHEMBL28643992 | 0.85 | ROCK2 (0.43) | BRD4METROCK2KDRFLT3 | |
| SCHEMBL20443319 | 0.83 | ROCK2 (0.40) | BRD4METROCK2KDRFLT3 | |
| SCHEMBL20443239 | 0.83 | S1PR4 (0.41) | BRD4METROCK2TRPA1CCNK | |
| SCHEMBL20443297 | 0.82 | ROCK2 (0.40) | BRD4METROCK2KDRFLT3 | |
| SCHEMBL20443013 | 0.81 | ROCK2 (0.39) | BRD4METROCK2KDRFLT3 | |
| SCHEMBL20442994 | 0.81 | BRD4 (0.53) | BRD4 | |
| SCHEMBL20442995 | 0.79 | ROCK2 (0.41) | BRD4METROCK2KDRFLT3 | |
| SCHEMBL20443032 | 0.78 | ROCK2 (0.40) | BRD4METROCK2KDRFLT3 | |
| SCHEMBL20442964 | 0.78 | BRD4 (0.47) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110198941-B | Pyrrolopyridine N-oxide derivative and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-09-28 | — | — | CN | disclosed |
| WO-2018137655-A1 | PYRROLO-PYRIDINES N-OXIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 江苏豪森药业集团有限公司 | 2018-08-02 | — | — | WO | disclosed |