Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | PPM1B | O75688 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SYNJ2 | O15056 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22799371 | 1.00 | ALDH1A1 (0.65) | ALDH1A1HPGDPOLBGAAMAPK1 | |
| SCHEMBL22799620 | 1.00 | ALDH1A1 (0.65) | ALDH1A1HPGDPOLBGAAMAPK1 | |
| SCHEMBL26811910 | 0.85 | ALDH1A1 (0.59) | ALDH1A1HPGDPOLBGAAMAPK1 | |
| SCHEMBL13675166 | 0.85 | ALDH1A1 (0.59) | ALDH1A1HPGDPOLBGAAMAPK1 | |
| SCHEMBL13871579 | 0.85 | ALDH1A1 (0.59) | ALDH1A1HPGDPOLBGAAMAPK1 | |
| SCHEMBL17822523 | 0.85 | ALDH1A1 (0.59) | ALDH1A1HPGDPOLBGAAMAPK1 | |
| SCHEMBL3257710 | 0.85 | ALDH1A1 (0.59) | ALDH1A1HPGDPOLBGAAMAPK1 | |
| SCHEMBL7892319 | 0.85 | ALDH1A1 (0.59) | ALDH1A1HPGDPOLBGAAMAPK1 | |
| SCHEMBL7257546 | 0.85 | ALDH1A1 (0.59) | ALDH1A1HPGDPOLBGAAMAPK1 | |
| SCHEMBL24674007 | 0.83 | ALDH1A1 (0.58) | ALDH1A1HPGDPOLBGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3573717-B1 | CYCLIC DINUCLEOTIDES AS STING AGONISTS | JANSSEN BIOTECH INC (US) | 2021-07-28 | — | — | EP | disclosed |
| WO-2018138684-A1 | CYCLIC DINUCLEOTIDES AS STING AGONISTS | JANSSEN BIOTECH, INC. (US) | 2018-08-02 | — | — | WO | disclosed |