Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.54 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 5/20 | 0.49 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11516210 | 0.86 | MAPK13 (0.53) | NPC1RAB9AMAPK14PIN1KDM4E | |
| SCHEMBL14002078 | 0.85 | MAPK14 (0.67) | MAPK14CSNK1DCSNK1EPTPN1KDM4E | |
| SCHEMBL20425689 | 0.84 | GAA (0.58) | MAPK14PIN1NPBWR1KDM4EALDH1A1 | |
| SCHEMBL23758282 | 0.83 | GAA (0.58) | NPC1RAB9AMAPK14KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL23736197 | 0.83 | GAA (0.57) | MAPK14PIN1NPBWR1KDM4EALDH1A1 | |
| SCHEMBL28460536 | 0.81 | PIN1 (0.62) | NPC1RAB9ANR1I3MAPK14PIN1 | |
| SCHEMBL20445314 | 0.80 | MAPK14 (0.61) | NPC1RAB9AMAPK14PIN1NPBWR1 | |
| SCHEMBL13830585 | 0.80 | GAA (0.56) | PTPN1KDM4EALDH1A1MAPT | |
| SCHEMBL8313104 | 0.79 | MEN1 (0.47) | RAB9AMAPK14PTPN1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL23736216 | 0.79 | MAPK14 (0.60) | NPC1RAB9AMAPK14PIN1NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11090289-B2 | Compositions and methods for blocking sodium channels | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2021-08-17 | — | — | US | disclosed |
| WO-2018140504-A1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | PATEL MANOJ K (US) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11090289-B2 | Compositions and methods for blocking sodium channels | SCN3A, SCN1B, SCN2B | NPC1 483/4885RAB9A 2068/4885NR1I3 1574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.