Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 16/20 | 0.81 |
| ▸ | PDE5A | O76074 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.58 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | METAP1 | P53582 | 1/20 | 0.53 |
| ▸ | CBFB | Q13951 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23758274 | 0.89 | AMY1A (0.64) | AMY1APDE5A | |
| SCHEMBL1483091 | 0.83 | AMY1A (0.65) | AMY1APDE5AKDM4EALDH1A1 | |
| SCHEMBL3332738 | 0.83 | AMY1A (0.67) | AMY1APDE5AKDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL3194238 | 0.82 | PDE5A (0.62) | AMY1APDE5AKDM4EMEN1ALDH1A1 | |
| SCHEMBL31027930 | 0.82 | AMY1A (0.76) | AMY1APDE5AKDM4EALDH1A1TP53 | |
| SCHEMBL2096956 | 0.82 | AMY1A (0.76) | AMY1APDE5AKDM4EALDH1A1TP53 | |
| SCHEMBL3168707 | 0.79 | HDAC6 (0.62) | AMY1APDE5ATP53MAPT | |
| SCHEMBL1482545 | 0.79 | PDE5A (0.59) | AMY1APDE5AKDM4EALDH1A1CYP3A4 | |
| SCHEMBL1248687 | 0.79 | HDAC6 (0.61) | AMY1ATP53MAPTKMT2A | |
| SCHEMBL7393993 | 0.78 | AMY1A (0.64) | AMY1AKDM4EMEN1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12403128-B2 | Compositions and methods for blocking sodium channels | Univerity of Virginia Patent Foundation (US) | 2025-09-02 | — | — | US | disclosed |
| US-20220047554-A1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | UNIVERSITY OF VIRGINIA | 2022-02-17 | — | — | US | disclosed |
| US-11090289-B2 | Compositions and methods for blocking sodium channels | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2021-08-17 | — | — | US | disclosed |
| US-11090289-B2 | Compositions and methods for blocking sodium channels | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2021-08-17 | — | — | US | disclosed |
| WO-2018140504-A1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | PATEL MANOJ K (US) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12403128-B2 | Compositions and methods for blocking sodium channels | SCN3A, SCN1B, SCN2B | AMY1A 2750/4885PDE5A 295/4885KDM4E 4354/4885 |
| US-11090289-B2 | Compositions and methods for blocking sodium channels | SCN3A, SCN1B, SCN2B | AMY1A 2750/4885PDE5A 295/4885KDM4E 4354/4885 |
| US-20220047554-A1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | SCN3A, SCN1B, SCN2B | AMY1A 2750/4885PDE5A 295/4885KDM4E 4354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.