Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 11/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20446590 | 0.83 | KLKB1 (0.42) | CTSCPARP1KLKB1F10 | |
| SCHEMBL20446536 | 0.81 | KLKB1 (0.38) | PARP1KLKB1GAAF10 | |
| SCHEMBL20446523 | 0.81 | KLKB1 (0.50) | CTSCKLKB1GAAF10HCRTR1 | |
| SCHEMBL20446599 | 0.73 | GAA (0.37) | PARP1KLKB1GAA | |
| SCHEMBL17064730 | 0.71 | GAA (0.35) | PARP1KLKB1GAA | |
| SCHEMBL24012079 | 0.70 | CTSC (0.41) | CTSCKLKB1GAAHCRTR1HCRTR2 | |
| SCHEMBL20446587 | 0.69 | KLKB1 (0.45) | CTSCPARP1KLKB1 | |
| SCHEMBL17064440 | 0.68 | GAA (0.37) | PARP1GAA | |
| SCHEMBL20446582 | 0.67 | CTSC (0.37) | CTSCPARP1KLKB1 | |
| SCHEMBL20446530 | 0.67 | KLKB1 (0.38) | CTSCPARP1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3355890-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |