Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | EIF4E | P06730 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3547753 | 0.78 | SLC6A9 (0.44) | HRH3SLC6A9SLC6A5TSHRKDM4E | |
| SCHEMBL4973482 | 0.75 | SLC6A9 (0.42) | HRH3SLC6A9SLC6A5HPGDTSHR | |
| SCHEMBL2027225 | 0.73 | TYR (0.61) | TYRHPGDPIN1KDM4EALDH1A1 | |
| SCHEMBL3543022 | 0.73 | TYR (0.61) | TYRHPGDPIN1KDM4EALDH1A1 | |
| SCHEMBL2026846 | 0.73 | PDE4D (0.38) | HRH3ACHETYRHTR2BEIF4E | |
| SCHEMBL2026844 | 0.73 | TYR (0.44) | HRH3TYRHPGDPIN1KDM4E | |
| SCHEMBL2026842 | 0.73 | TYR (0.44) | HRH3TYRHPGDPIN1KDM4E | |
| SCHEMBL5662015 | 0.71 | HTT (0.46) | HRH3ACHEHTR2BHTR2CHPGD | |
| SCHEMBL3536540 | 0.70 | CNR1 (0.45) | HRH3HTR2CNPC1RAB9A | |
| SCHEMBL3537686 | 0.70 | ACHE (0.62) | ACHEHTR2BEIF4EMAOAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | claimed |
| WO-2011068927-A2 | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |