Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2048375 | 1.00 | OPRM1 (0.40) | OPRM1OPRK1ITGB3ITGA2BOPRD1 | |
| SCHEMBL2046087 | 1.00 | OPRM1 (0.40) | OPRM1OPRK1ITGB3ITGA2BOPRD1 | |
| SCHEMBL3408615 | 0.80 | ESR1 (0.45) | OPRM1OPRK1OPRD1NQO2MTNR1A | |
| SCHEMBL4621828 | 0.77 | ESR2 (0.43) | OPRM1OPRK1ITGB3ITGA2BMEN1 | |
| SCHEMBL2784278 | 0.76 | ITGB3 (0.47) | OPRM1OPRK1ITGB3ITGA2BMEN1 | |
| SCHEMBL2784223 | 0.76 | ITGB3 (0.47) | OPRM1OPRK1ITGB3ITGA2BMEN1 | |
| SCHEMBL2786680 | 0.76 | ITGB3 (0.47) | OPRM1OPRK1ITGB3ITGA2BMEN1 | |
| SCHEMBL2050706 | 0.75 | OPRM1 (0.43) | OPRM1OPRK1ITGB3ITGA2BOPRD1 | |
| SCHEMBL2045762 | 0.75 | OPRM1 (0.43) | OPRM1OPRK1ITGB3ITGA2BOPRD1 | |
| SCHEMBL6787868 | 0.72 | ITGB3 (0.66) | ITGB3ITGA2BITGB1ITGAVITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2329821-A1 | Treatment of ocular neovascular disorders such as macular degeneration, angiod streaks, uveitis and macular edema | GlaxoSmithKline LLC (US) | 2011-06-08 | — | — | EP | disclosed |