⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2445375 | 0.80 | — | — | |
| SCHEMBL29023462 | 0.75 | ACHE (0.34) | — | |
| SCHEMBL12470482 | 0.75 | MKNK1 (0.40) | — | |
| SCHEMBL8418372 | 0.66 | TSHR (0.35) | — | |
| SCHEMBL387530 | 0.65 | — | — | |
| SCHEMBL16287742 | 0.65 | — | — | |
| SCHEMBL490251 | 0.64 | KDM4E (0.42) | — | |
| SCHEMBL5857066 | 0.64 | KDM4E (0.42) | — | |
| SCHEMBL6332776 | 0.64 | — | — | |
| SCHEMBL7498207 | 0.63 | KMT2A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633716-A4 | BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2008-03-26 | — | — | EP | claimed |
| US-7129264-B2 | Biarylmethyl indolines and indoles as antithromboembolic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-10-31 | — | — | US | claimed |
| EP-1633716-A2 | BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2006-03-15 | — | — | EP | claimed |
| WO-2004094372-A2 | COMPOUNDS USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-11-04 | — | — | WO | claimed |
| US-20040220206-A1 | Biarylmethyl indolines, indoles and tetrahydroquinolines, useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2004-11-04 | — | — | US | claimed |
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | BAXTER ONCOLOGY GMBH | 2003-08-21 | — | — | US | claimed |
| EP-1276720-A2 | 2-ACYL INDOL DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | ASTA Medica AG (DE) | 2003-01-22 | — | — | EP | claimed |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | BECKERS THOMAS (DE) | 2002-07-11 | — | — | US | claimed |
| WO-2001082909-A2 | 2-ACYL INDOL DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | BAXTER HEALTHCARE SA (DE) | 2001-11-08 | — | — | WO | claimed |
| US-20230150951-A1 | 2,5- OR 2,6-DISUBSTITUTED HYDROQUINONE DERIVATIVES WITH AT LEAST ONE CARBOXY, SULFO OR AMIDO GROUP USEFUL AS MEDICAMENTS | OM PHARMA SA (CH) | 2023-05-18 | — | — | US | disclosed |
| EP-3878837-A1 | 2,5- OR 2,6-DISUBSTITUTED HYDROQUINONE DERIVATIVES WITH AT LEAST ONE CARBOXY, SULFO OR AMIDO GROUP USEFUL AS MEDICAMENTS | OM Pharma SA (CH) | 2021-09-15 | — | — | EP | disclosed |
| CN-110746479-B | Compound and preparation method and application thereof | 山东师范大学 | 2021-01-08 | — | — | CN | disclosed |
| CN-110746479-A | Compound and preparation method and application thereof | 山东师范大学 | 2020-02-04 | — | — | CN | disclosed |
| EP-2960247-A1 | PHENYL-ALPHA-D-MANNOSIDES FOR USE IN THE TREATMENT OF BACTERIAL INFECTIONS CAUSED BY ESCHERICHIA COLI | University of Basel (CH) | 2015-12-30 | — | — | EP | disclosed |
| US-6121279-A | PHOSPHODIESTERASE INHIBITOR FOR TREATING RESPIRATORY SYSTEM DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-09-19 | — | — | US | disclosed |
| WO-2000042017-A1 | PHENANTHRIDINE-N-OXIDES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |
| EP-1000035-A1 | SUBSTITUTED 6-PHENYLPHENANTHRIDINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005113-A1 | SUBSTITUTED 6-PHENYLPHENANTHRIDINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1999-02-04 | — | — | WO | disclosed |
| WO-1994011365-A1 | SUBSTITUTED BENZIMIDAZOLES AND QUINAZOLINES AS ANTIHYPERTENSIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-05-26 | — | — | WO | disclosed |
| EP-0154190-A1 | Pyridones | MERCK PATENT GmbH (DE) | 1985-09-11 | — | — | EP | disclosed |