SCHEMBL5857066

SCHEMBL5857066

O=C(O)c1[c]ccc(C(=O)O)c1.O=C(O)c1[c]ccc(C(=O)O)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.42
MAPT P10636 3/20 0.42
ALDH1A1 P00352 2/20 0.42
KDM6B O15054 1/20 0.42
TET3 O43151 1/20 0.42
KDM4A O75164 1/20 0.42
BBOX1 O75936 1/20 0.42
KDM5A P29375 1/20 0.42
KDM5C P41229 1/20 0.42
ASPH Q12797 1/20 0.42
KDM4D Q6B0I6 1/20 0.42
TET2 Q6N021 1/20 0.42
ALKBH5 Q6P6C2 1/20 0.42
KDM7A Q6ZMT4 1/20 0.42
KDM8 Q8N371 1/20 0.42
TET1 Q8NFU7 1/20 0.42
EGLN2 Q96KS0 1/20 0.42
FTO Q9C0B1 1/20 0.42
EGLN1 Q9GZT9 1/20 0.42
KDM4C Q9H3R0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL490251 1.00 KDM4E (0.42) KDM4EMAPTALDH1A1KDM6BTET3
SCHEMBL4626841 0.85 PARP1 (0.41) MAPTTSHRPOLBL3MBTL1HSD17B10
SCHEMBL4628388 0.81 KDM4E (0.50) KDM4EMAPTALDH1A1KDM6BKDM5C
SCHEMBL2467941 0.77 CA12 (0.46) KDM4EMAPTALDH1A1KDM6BTET3
SCHEMBL28916660 0.77 SLC7A5 (0.45) KDM4EMAPTALDH1A1KDM6BKDM5C
SCHEMBL3735378 0.76 CSNK2A1 (0.41) ALDH1A1CA12CA1CA2CA6
SCHEMBL1205901 0.76 TSHR (0.48) KDM4EMAPTALDH1A1TSHRTP53
SCHEMBL444146 0.76 GABRP (0.44) KDM4EMAPTALDH1A1KDM6BTET3
SCHEMBL3045441 0.76 KDM4E (0.41) KDM4EMAPTALDH1A1POLBGAA
SCHEMBL6302545 0.76 TPMT (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7022772-B2 Optical film comprising polyarylates containing bis-(hydroxyphenyl)-fluorene-ortho-disubstituted bisphenols FERRARIA TECHNOLOGIES S.P.A. (IT) 2006-04-04 US disclosed
EP-1205772-B1 Optical film comprising polyarylates containing bis-(hydroxyphenyl)-fluorene-ortho-disubstituted bisphenols FERRANIA SPA (IT) 2005-03-09 EP disclosed
US-20040192848-A1 Optical film comprising polyarylates containing bis-(hydroxyphenyl)-fluorene-ortho-disubstituted bisphenols FERRANIA, S.P.A 2004-09-30 US disclosed
US-6632886-B2 Light stability, heat resistance, light transparency, high glass transition temperature (Tg) and good mechanical properties FERRANIA, S.P.A. (IT) 2003-10-14 US disclosed
US-20020091200-A1 Optical film comprising polyarylates containing bis-(hydroxyphenyl)-fluorene-ortho-disubstituted bisphenols FERRANIA S.P.A. 2002-07-11 US disclosed
EP-1205772-A2 Optical film comprising polyarylates containing bis-(hydroxyphenyl)-fluorene-ortho-disubstituted bisphenols FERRANIA S.p.A. (IT) 2002-05-15 EP disclosed