Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.45 |
| ▸ | S100A4 | P26447 | 2/20 | 0.35 |
| ▸ | STS | P08842 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6521534 | 0.81 | GPR35 (0.46) | GPR35S100A4STSHSP90AA1MEN1 | |
| SCHEMBL6184572 | 0.77 | TRPA1 (0.38) | MEN1KMT2AESR1ESR2MAPT | |
| SCHEMBL19899567 | 0.77 | GPR35 (0.55) | GPR35S100A4STSHSP90AA1MEN1 | |
| SCHEMBL6184401 | 0.76 | AR (0.41) | MEN1KMT2AALDH1A1TDP1GAA | |
| SCHEMBL8935115 | 0.76 | DNMT3B (0.40) | MEN1KMT2AALDH1A1TDP1GAA | |
| SCHEMBL6184452 | 0.74 | ESR1 (0.32) | MEN1KMT2AESR1ESR2 | |
| SCHEMBL6186797 | 0.71 | CA1 (0.38) | ALDH1A1ESR1ESR2MAPT | |
| SCHEMBL31473755 | 0.70 | GPR35 (0.44) | GPR35S100A4STSMEN1KMT2A | |
| SCHEMBL70533 | 0.70 | GPR35 (0.75) | GPR35S100A4ALDH1A1TDP1ESR1 | |
| SCHEMBL28687501 | 0.69 | GPR35 (0.42) | GPR35S100A4HSP90AA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011140202-A2 | MIF MODULATORS | YALE UNIVERSITY (US) | 2011-11-10 | — | — | WO | disclosed |
| EP-2326631-A2 | MIF MODULATORS | Yale University (US) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010021693-A2 | MIF MODULATORS | YALE UNIVERSITY (US) | 2010-02-25 | — | — | WO | disclosed |
| EP-1581218-A1 | EPOTHILONE ANALOGS FOR SITE SPECIFIC DELIVERY IN THE TREATMENT OF PROLIFERATIVE DISEASES | Schering AG (DE) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050089-A1 | EPOTHILONE ANALOGS FOR SITE SPECIFIC DELIVERY IN THE TREATMENT OF PROLIFERATIVE DISEASES | SCHERING AG (DE) | 2004-06-17 | — | — | WO | disclosed |