Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 5/20 | 0.74 |
| ▸ | SUZ12 | Q15022 | 5/20 | 0.74 |
| ▸ | EZH2 | Q15910 | 5/20 | 0.74 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.74 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.74 |
| ▸ | IDO1 | P14902 | 10/20 | 0.60 |
| ▸ | TDO2 | P48775 | 9/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14417701 | 0.85 | EED (1.00) | EEDSUZ12EZH2RBBP4RBBP7 | |
| SCHEMBL14417695 | 0.85 | EED (1.00) | EEDSUZ12EZH2RBBP4RBBP7 | |
| SCHEMBL16152287 | 0.85 | EED (1.00) | EEDSUZ12EZH2RBBP4RBBP7 | |
| SCHEMBL30923422 | 0.75 | IDO1 (1.00) | EEDSUZ12EZH2RBBP4RBBP7 | |
| SCHEMBL29539317 | 0.65 | IDO1 (0.77) | EEDSUZ12EZH2RBBP4RBBP7 | |
| SCHEMBL16152326 | 0.65 | EED (0.78) | EEDSUZ12EZH2RBBP4RBBP7 | |
| SCHEMBL30017207 | 0.64 | IDO1 (1.00) | EEDSUZ12EZH2RBBP4RBBP7 | |
| SCHEMBL30978884 | 0.63 | IDO1 (0.61) | EEDSUZ12EZH2RBBP4RBBP7 | |
| Tanshinone Iia SCHEMBL2026738 | 0.62 | EED (1.00) | EEDSUZ12EZH2RBBP4RBBP7 | |
| SCHEMBL18020194 | 0.62 | CES1 (0.46) | EEDSUZ12EZH2RBBP4RBBP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2786990-B1 | 2-AMINATED METHYLENE OR 2-ESTERIFIED METHYLENE TANSHINONE DERIVATIVES, AND PREPARATION METHOD AND APPLICATION THEREOF | HANGZHOU BENSHENG PHARMACEUTICAL CO LTD (CN) | 2018-08-08 | — | — | EP | disclosed |