Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13698123 | 1.00 | OPRM1 (0.42) | OPRM1SLC6A4SLC6A3SLC6A2OPRL1 | |
| SCHEMBL17303200 | 1.00 | OPRM1 (0.42) | OPRM1SLC6A4SLC6A3SLC6A2OPRL1 | |
| SCHEMBL13698121 | 1.00 | OPRM1 (0.42) | OPRM1SLC6A4SLC6A3SLC6A2OPRL1 | |
| SCHEMBL4194504 | 1.00 | OPRM1 (0.42) | OPRM1SLC6A4SLC6A3SLC6A2OPRL1 | |
| SCHEMBL4185836 | 1.00 | OPRM1 (0.42) | OPRM1SLC6A4SLC6A3SLC6A2OPRL1 | |
| SCHEMBL13698275 | 0.81 | OPRM1 (0.46) | OPRM1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL4402453 | 0.81 | PTGS2 (0.36) | OPRM1 | |
| SCHEMBL8927314 | 0.81 | PTGS2 (0.36) | OPRM1 | |
| SCHEMBL13224854 | 0.81 | PTGS2 (0.36) | OPRM1 | |
| SCHEMBL13224856 | 0.81 | PTGS2 (0.36) | OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2719384-B1 | Novel 1-naphthyl-3-azabicyclo[3.1.0]hexanes:preparation and use to treat neuropsychiatric disorders | OTSUKA AMERICA PHARMACEUTICAL INC (US) | 2018-08-08 | — | — | EP | disclosed |