Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 18/20 | 0.78 |
| ▸ | PTK2B | Q14289 | 16/20 | 0.78 |
| ▸ | AURKA | O14965 | 2/20 | 0.78 |
| ▸ | PLK4 | O00444 | 1/20 | 0.78 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.78 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.78 |
| ▸ | JAK2 | O60674 | 1/20 | 0.78 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.78 |
| ▸ | STK16 | O75716 | 1/20 | 0.78 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.78 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.78 |
| ▸ | PAK4 | O96013 | 1/20 | 0.78 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.78 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.78 |
| ▸ | PRKCG | P05129 | 1/20 | 0.78 |
| ▸ | INSR | P06213 | 1/20 | 0.78 |
| ▸ | LCK | P06239 | 1/20 | 0.78 |
| ▸ | FYN | P06241 | 1/20 | 0.78 |
| ▸ | CDK1 | P06493 | 1/20 | 0.78 |
| ▸ | LYN | P07948 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pf-00562271 SCHEMBL1206959 | 0.88 | PTK2 (1.00) | PTK2PTK2BAURKAPLK4PDPK1 | |
| Pf-00562271 SCHEMBL29637167 | 0.88 | PTK2 (1.00) | PTK2PTK2BAURKAPLK4PDPK1 | |
| Pf-00562271 SCHEMBL29381854 | 0.88 | PTK2 (1.00) | PTK2PTK2BAURKAPLK4PDPK1 | |
| Pf-00562271 SCHEMBL21062022 | 0.87 | PTK2 (0.99) | PTK2PTK2BAURKAPLK4PDPK1 | |
| Pf-00562271 SCHEMBL29496512 | 0.87 | PTK2 (0.99) | PTK2PTK2BAURKAPLK4PDPK1 | |
| SCHEMBL1207932 | 0.85 | PTK2 (0.80) | PTK2PTK2BAURKAPLK4PDPK1 | |
| SCHEMBL5504547 | 0.85 | PTK2 (0.84) | PTK2PTK2BAURKAPLK4PDPK1 | |
| SCHEMBL5501091 | 0.85 | PTK2 (0.84) | PTK2PTK2BAURKAPLK4PDPK1 | |
| SCHEMBL29157673 | 0.83 | PTK2B (0.72) | PTK2PTK2BAURKAPLK4PDPK1 | |
| SCHEMBL3148510 | 0.83 | PTK2B (0.82) | PTK2PTK2BAURKAPLK4PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020006724-A1 | COMPOUND FOR TARGETED DEGRADATION OF FAK PROTEIN AND USE THEREOF | 清华大学 | 2020-01-09 | — | — | WO | disclosed |
| EP-2675793-B1 | FAK INHIBITORS | CANCER THERAPEUTICS CRC PTY LTD (AU) | 2018-08-08 | — | — | EP | disclosed |