Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 6/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | BRS3 | P32247 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20459545 | 0.87 | KCNN4 (0.35) | VNN1 | |
| SCHEMBL17108576 | 0.82 | VNN1 (0.34) | VNN1 | |
| SCHEMBL20018530 | 0.79 | VNN1 (0.33) | VNN1 | |
| SCHEMBL17108575 | 0.75 | VNN1 (0.34) | VNN1 | |
| SCHEMBL20459561 | 0.74 | GRIN2B (0.33) | VNN1 | |
| SCHEMBL20018625 | 0.73 | VNN1 (0.31) | VNN1 | |
| SCHEMBL926070 | 0.64 | KCNN4 (0.35) | VNN1 | |
| SCHEMBL20459591 | 0.63 | TACR1 (0.31) | VNN1 | |
| SCHEMBL19672102 | 0.63 | VNN1 (0.31) | VNN1 | |
| SCHEMBL20018601 | 0.62 | VNN1 (0.38) | VNN1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900241-B1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2018-08-08 | — | — | EP | disclosed |