SCHEMBL20460281

SCHEMBL20460281

CCNC(=O)c1cc(OC)c2ccccc2n1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.68
P2RY12 Q9H244 17/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20460301 0.90 ALOX15 (0.64) ALOX15P2RY12
SCHEMBL20460357 0.88 ALOX15 (0.66) ALOX15P2RY12
SCHEMBL7030966 0.88 P2RY12 (0.66) ALOX15P2RY12
SCHEMBL20460330 0.87 P2RY12 (0.66) ALOX15P2RY12
SCHEMBL23710419 0.87 ALOX15 (0.64) ALOX15P2RY12
SCHEMBL20460343 0.86 P2RY12 (0.68) ALOX15P2RY12
SCHEMBL2073956 0.86 ALOX15 (0.71) ALOX15P2RY12
SCHEMBL5717811 0.86 P2RY12 (0.64) ALOX15P2RY12
SCHEMBL20460325 0.86 ALOX15 (0.63) ALOX15P2RY12
SCHEMBL13035843 0.85 ALOX15 (0.73) ALOX15P2RY12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2288351-B1 NOVEL PYRROLIDONE DERIVATIVES FOR USE AS METAP-2 INHIBITORS MERCK PATENT GMBH (DE) 2018-08-08 EP disclosed