Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PER2 | O15055 | 13/20 | 0.63 |
| ▸ | CRY1 | Q16526 | 13/20 | 0.63 |
| ▸ | CRY2 | Q49AN0 | 13/20 | 0.63 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | NPY1R | P25929 | 1/20 | 0.56 |
| ▸ | NPY2R | P49146 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20462245 | 0.95 | PER2 (0.65) | PER2CRY1CRY2DNM1TSHR | |
| SCHEMBL20462249 | 0.95 | PER2 (0.65) | PER2CRY1CRY2DNM1TSHR | |
| SCHEMBL20462199 | 0.89 | PER2 (0.65) | PER2CRY1CRY2DNM1TSHR | |
| SCHEMBL20462299 | 0.79 | PER2 (0.67) | PER2CRY1CRY2 | |
| SCHEMBL20462257 | 0.79 | PER2 (0.67) | PER2CRY1CRY2 | |
| SCHEMBL20462138 | 0.78 | PER2 (0.65) | PER2CRY1CRY2DNM1TSHR | |
| SCHEMBL15380004 | 0.78 | PER2 (1.00) | PER2CRY1CRY2TSHRALDH1A1 | |
| SCHEMBL20462195 | 0.77 | PER2 (0.67) | PER2CRY1CRY2DNM1TSHR | |
| SCHEMBL20462255 | 0.74 | PER2 (0.67) | PER2CRY1CRY2DNM1TSHR | |
| SCHEMBL15380593 | 0.73 | PER2 (1.00) | PER2CRY1CRY2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855458-B1 | CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS | RESET THERAPEUTICS INC (US) | 2018-08-08 | — | — | EP | disclosed |