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Sugi Predict / Compounds / SCHEMBL20462138

SCHEMBL20462138

SCHEMBL20462138

CSN(CC(O)Cn1c2ccccc2c2ccccc21)C1CC1(C)C

nearest known ligand 0.65

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ PER2 O15055 15/20 0.65
▸ CRY1 Q16526 14/20 0.65
▸ CRY2 Q49AN0 14/20 0.65
▸ DNM1 Q05193 3/20 0.56
▸ TSHR P16473 1/20 0.53
▸ NPY1R P25929 1/20 0.53
▸ NPY2R P49146 1/20 0.53
▸ BACE1 P56817 1/20 0.50
▸ ALDH1A1 P00352 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20462195 0.82 PER2 (0.67) PER2CRY1CRY2DNM1TSHR
SCHEMBL20462289 0.80 PER2 (0.65) PER2CRY1CRY2DNM1TSHR
SCHEMBL20462144 0.80 PER2 (0.65) PER2CRY1CRY2DNM1TSHR
SCHEMBL20462255 0.79 PER2 (0.67) PER2CRY1CRY2DNM1TSHR
SCHEMBL15380741 0.79 PER2 (1.00) PER2CRY1CRY2
SCHEMBL20462172 0.78 PER2 (0.69) PER2CRY1CRY2DNM1TSHR
SCHEMBL20462136 0.78 PER2 (0.63) PER2CRY1CRY2DNM1TSHR
SCHEMBL20462227 0.77 PER2 (0.67) PER2CRY1CRY2DNM1TSHR
SCHEMBL20462249 0.76 PER2 (0.65) PER2CRY1CRY2DNM1TSHR
SCHEMBL20462245 0.76 PER2 (0.65) PER2CRY1CRY2DNM1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2855458-B1 CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS RESET THERAPEUTICS INC (US) 2018-08-08 — — EP disclosed