Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 1/20 | 0.47 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.47 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 3/20 | 0.40 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18539756 | 0.80 | GNAI3 (0.56) | GNAI3GNAO1GNAI1HRH2HRH1 | |
| SCHEMBL6942292 | 0.80 | GNAI3 (0.47) | GNAI3GNAO1GNAI1HRH2HRH1 | |
| SCHEMBL20075918 | 0.79 | GNAI3 (0.46) | GNAI3GNAO1GNAI1HRH2HRH1 | |
| SCHEMBL13668229 | 0.78 | GNAI3 (0.46) | GNAI3GNAO1GNAI1HRH2HRH1 | |
| SCHEMBL24481186 | 0.77 | GNAI3 (0.53) | GNAI3GNAO1GNAI1HRH2HRH1 | |
| SCHEMBL16900142 | 0.77 | GNAI3 (0.53) | GNAI3GNAO1GNAI1HRH2HRH1 | |
| SCHEMBL16826736 | 0.77 | GNAI3 (0.53) | GNAI3GNAO1GNAI1HRH2HRH1 | |
| SCHEMBL20648946 | 0.75 | GNAO1 (0.60) | GNAI3GNAO1GNAI1HRH2HRH1 | |
| SCHEMBL1957601 | 0.75 | GNAI3 (0.50) | GNAI3GNAO1GNAI1HRH2HRH1 | |
| SCHEMBL6941686 | 0.74 | GNAI3 (0.59) | GNAI3GNAO1GNAI1HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660004-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2020-06-03 | — | — | EP | disclosed |
| WO-2018144649-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | Arvinas, Inc. (US) | 2018-08-09 | — | — | WO | disclosed |