SCHEMBL2046540

SCHEMBL2046540

ClC(Cl)(Cl)c1ccccc1-c1ccccc1C(Cl)(Cl)Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.43
CYP2A6 P11509 1/20 0.38
LMNA P02545 3/20 0.37
KCNN4 O15554 1/20 0.36
MAPK1 P28482 3/20 0.35
TDP1 Q9NUW8 3/20 0.35
CYP3A4 P08684 2/20 0.35
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
HSD11B1 P28845 2/20 0.33
IDO1 P14902 2/20 0.33
CDC25B P30305 2/20 0.33
DNMT1 P26358 1/20 0.33
DNMT3L Q9UJW3 1/20 0.33
DNMT3A Q9Y6K1 1/20 0.33
NPC1 O15118 4/20 0.32
SMN1; SMN2 Q16637 4/20 0.32
RAB9A P51151 3/20 0.32
TP53 P04637 2/20 0.32
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11108795 0.84 CYP2A6 (0.54) TSHRCYP2A6KCNN4MAPK1TDP1
SCHEMBL30318973 0.83 TSHR (0.50) TSHRCYP2A6LMNAKCNN4MAPK1
SCHEMBL545083 0.83 TSHR (0.50) TSHRCYP2A6LMNAKCNN4MAPK1
Benzene SCHEMBL21048983 0.80 TSHR (0.56) TSHRCYP2A6LMNAKCNN4MAPK1
SCHEMBL197704 0.75 TSHR (0.53) TSHRCYP2A6LMNAKCNN4MAPK1
SCHEMBL29617470 0.75 TSHR (0.53) TSHRCYP2A6LMNAKCNN4MAPK1
SCHEMBL11553538 0.75 CYP1A2 (0.45) TSHRCYP2A6LMNAKCNN4MAPK1
SCHEMBL11757846 0.75 TSHR (0.43) TSHRCYP2A6LMNAKCNN4MAPK1
Hydrochloric Acid SCHEMBL9269217 0.73 TSHR (0.50) TSHRCYP2A6LMNAKCNN4MAPK1
Fluoride SCHEMBL11730018 0.73 TSHR (0.50) TSHRCYP2A6LMNAKCNN4MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7960488-B2 Aluminoxane compositions, their preparation, and their use in catalysis ALBEMARLE CORPORATION (US) 2011-06-14 US disclosed
US-20090088541-A1 ALUMINOXANE COMPOSITIONS, THEIR PREPARATION, AND THEIR USE IN CATALYSIS ALBEMARLE CORPORATION (US) 2009-04-02 US disclosed
EP-1701963-A1 HALOALUMINOXANE COMPOSITIONS, THEIR PREPARATION, AND THEIR USE IN CATALYSIS ALBEMARLE CORPORATION (US) 2006-09-20 EP disclosed
WO-2005066191-A1 HALOALUMINOXANE COMPOSITIONS, THEIR PREPARATION, AND THEIR USE IN CATALYSIS ALBEMARLE CORPORATION (US) 2005-07-21 WO disclosed