Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 4/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20468861 | 0.81 | ALDH1A1 (0.50) | ALDH1A1CYP2D6HSD17B10CYP3A4CYP1A2 | |
| SCHEMBL20468947 | 0.80 | ALDH1A1 (0.46) | ALDH1A1CYP2D6HSD17B10CYP3A4CYP1A2 | |
| SCHEMBL20468863 | 0.79 | OGA (0.45) | ALDH1A1CYP2D6HSD17B10CYP3A4CYP1A2 | |
| SCHEMBL20469191 | 0.77 | CYP3A4 (0.48) | ALDH1A1CYP2D6HSD17B10CYP3A4CYP1A2 | |
| SCHEMBL20468946 | 0.76 | OGA (0.45) | ALDH1A1CYP2D6HSD17B10CYP3A4CYP1A2 | |
| SCHEMBL20469180 | 0.75 | CYP11B1 (0.47) | ALDH1A1CYP2D6HSD17B10CYP3A4CYP1A2 | |
| SCHEMBL20468965 | 0.75 | ALDH1A1 (0.43) | ALDH1A1CYP2D6HSD17B10CYP3A4CYP1A2 | |
| SCHEMBL20468975 | 0.74 | CYP3A4 (0.43) | ALDH1A1CYP2D6HSD17B10CYP3A4CYP1A2 | |
| SCHEMBL30328553 | 0.74 | PIM1 (0.36) | ALDH1A1CYP2D6HSD17B10CYP3A4CYP1A2 | |
| SCHEMBL20468866 | 0.74 | ALDH1A1 (0.46) | ALDH1A1CYP2D6HSD17B10CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048267-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2020-02-13 | — | — | US | disclosed |
| WO-2018141984-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2018-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048267-A1 | OGA INHIBITOR COMPOUNDS | OGA, OGT, GRN | ALDH1A1 3839/4885CYP2D6 4092/4885HSD17B10 2463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.