Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 4/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30329392 | 0.82 | PIM1 (0.36) | PIM1PIM3PIM2ALDH1A1HSD17B10 | |
| SCHEMBL25163969 | 0.79 | TSHR (0.41) | PIM1PIM3PIM2ALDH1A1HSD17B10 | |
| SCHEMBL30328597 | 0.79 | PIM1 (0.31) | PIM1PIM3PIM2ALDH1A1HSD17B10 | |
| SCHEMBL30328282 | 0.76 | ACACA (0.37) | JAK2JAK1TYK2JAK3TSHR | |
| SCHEMBL20468974 | 0.74 | ALDH1A1 (0.45) | PIM1PIM3PIM2ALDH1A1HSD17B10 | |
| SCHEMBL30327738 | 0.73 | PIM1 (0.40) | PIM1PIM3PIM2ALDH1A1HSD17B10 | |
| SCHEMBL30329246 | 0.72 | PIM1 (0.36) | PIM1PIM3PIM2ALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL30327910 | 0.72 | PIM1 (0.40) | PIM1PIM3PIM2ALDH1A1HSD17B10 | |
| SCHEMBL26337633 | 0.72 | TLR7 (0.44) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL30329217 | 0.72 | ROCK2 (0.40) | PIM1PIM3PIM2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415706-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | Vanqua Bio, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064343-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | VANQUA BIO, INC. (US) | 2023-04-20 | — | — | WO | disclosed |