Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 15/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18701704 | 1.00 | HSD11B1 (0.49) | HSD11B1CNR2RIPK1ALDH1A1 | |
| SCHEMBL18701702 | 1.00 | HSD11B1 (0.49) | HSD11B1CNR2RIPK1ALDH1A1 | |
| SCHEMBL18711708 | 1.00 | HSD11B1 (0.49) | HSD11B1CNR2RIPK1ALDH1A1 | |
| SCHEMBL18701707 | 1.00 | HSD11B1 (0.49) | HSD11B1CNR2RIPK1ALDH1A1 | |
| SCHEMBL13888052 | 0.89 | RIPK1 (0.46) | HSD11B1CNR2RIPK1ALDH1A1 | |
| SCHEMBL18701700 | 0.82 | DPP4 (0.40) | RIPK1ALDH1A1 | |
| SCHEMBL18478535 | 0.79 | HSD11B1 (0.53) | HSD11B1CNR2 | |
| SCHEMBL18711710 | 0.79 | HSD11B1 (0.53) | HSD11B1CNR2 | |
| SCHEMBL879232 | 0.79 | HSD11B1 (0.53) | HSD11B1CNR2 | |
| SCHEMBL18711711 | 0.79 | HSD11B1 (0.53) | HSD11B1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10246429-B2 | Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use | AMGEN INC. (US) | 2019-04-02 | — | — | US | disclosed |
| US-20180222876-A1 | VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2018-08-09 | — | — | US | disclosed |
| US-20180222876-A1 | VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2018-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222876-A1 | VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | BACE1, BACE2, APP | HSD11B1 1682/4885CNR2 1648/4885RIPK1 3101/4885 |
| US-10246429-B2 | Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use | BACE1, BACE2, APP | HSD11B1 1682/4885CNR2 1648/4885RIPK1 3101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.