Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23542090 | 0.88 | NPC1 (0.52) | SMN1; SMN2ALDH1A1KMT2AKDM4EHSD17B10 | |
| SCHEMBL23542081 | 0.87 | KMT2A (0.44) | SMN1; SMN2ALDH1A1KMT2AKDM4EHSD17B10 | |
| SCHEMBL23542077 | 0.84 | NPC1 (0.49) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL20469804 | 0.83 | NPC1 (0.47) | SMN1; SMN2ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL23542079 | 0.83 | RAB9A (0.55) | SMN1; SMN2GAAALDH1A1KMT2AKDM4E | |
| SCHEMBL20469732 | 0.83 | RAB9A (0.55) | SMN1; SMN2GAAALDH1A1KMT2AKDM4E | |
| SCHEMBL20469725 | 0.83 | NPC1 (0.61) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL23542070 | 0.83 | RAB9A (0.55) | SMN1; SMN2GAAALDH1A1KMT2AKDM4E | |
| SCHEMBL23542095 | 0.83 | RAB9A (0.47) | SMN1; SMN2ALDH1A1KMT2AKDM4EHSD17B10 | |
| SCHEMBL20469723 | 0.83 | FASN (0.49) | SMN1; SMN2KMT2ANPC1RAB9AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11040963-B2 | Piperazine derivatives for influenza virus inhibitions | JANSSEN VACCINES & PREVENTION B.V. (NL) | 2021-06-22 | — | — | US | disclosed |
| WO-2018141854-A1 | PIPERAZINE DERIVATIVES FOR INFLUENZA VIRUS INHIBITION | JANSSEN VACCINES & PREVENTION B.V. (NL) | 2018-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11040963-B2 | Piperazine derivatives for influenza virus inhibitions | HAVCR2, BAZ2A, MAVS | SMN1; SMN2 4850/4885GAA 2388/4885ALDH1A1 631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.