Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 9/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | MYLK | Q15746 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992208 | 0.84 | MAP3K5 (0.44) | MAP3K5TNFMYLK | |
| SCHEMBL22711043 | 0.82 | MAP3K5 (0.43) | MAP3K5TNFMYLK | |
| SCHEMBL935226 | 0.80 | MAP3K5 (0.62) | MAP3K5CHKA | |
| SCHEMBL16354007 | 0.80 | NPC1 (0.41) | MAP3K5TNFMYLK | |
| SCHEMBL20473179 | 0.80 | MAP3K5 (0.40) | MAP3K5TNFMYLK | |
| SCHEMBL993194 | 0.75 | MAP3K5 (0.45) | MAP3K5TNFMYLK | |
| SCHEMBL944473 | 0.75 | MAP3K5 (0.62) | MAP3K5CHKA | |
| SCHEMBL22738967 | 0.73 | MAP3K5 (0.45) | MAP3K5CHKATNFMYLKPDE4A | |
| SCHEMBL943988 | 0.71 | MAP3K5 (0.69) | MAP3K5KDRMYLK | |
| SCHEMBL944324 | 0.70 | MAP3K5 (0.60) | MAP3K5MYLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3363797-A1 | ORAL DOSAGE FORM OF APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2018-08-22 | — | — | EP | disclosed |