Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 16/20 | 0.45 |
| ▸ | MYLK | Q15746 | 6/20 | 0.37 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16354007 | 0.79 | NPC1 (0.41) | MAP3K5MYLKTNF | |
| SCHEMBL992208 | 0.79 | MAP3K5 (0.44) | MAP3K5MYLKTNF | |
| SCHEMBL952626 | 0.78 | MAP3K5 (0.67) | MAP3K5 | |
| SCHEMBL20473178 | 0.75 | MAP3K5 (0.41) | MAP3K5MYLKTNF | |
| SCHEMBL14482052 | 0.74 | MAP3K5 (0.45) | MAP3K5MYLKTNF | |
| SCHEMBL22711043 | 0.74 | MAP3K5 (0.43) | MAP3K5MYLKTNF | |
| SCHEMBL956897 | 0.73 | CBLB (0.43) | MAP3K5 | |
| SCHEMBL20473179 | 0.71 | MAP3K5 (0.40) | MAP3K5MYLKTNF | |
| SCHEMBL952233 | 0.71 | MYLK (0.46) | MAP3K5MYLKTNF | |
| SCHEMBL943988 | 0.70 | MAP3K5 (0.69) | MAP3K5MYLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |