Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 14/20 | 0.44 |
| ▸ | MYLK | Q15746 | 3/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22711043 | 0.85 | MAP3K5 (0.43) | MAP3K5MYLKTNFAGTR2 | |
| SCHEMBL20473178 | 0.84 | MAP3K5 (0.41) | MAP3K5MYLKTNF | |
| SCHEMBL20473179 | 0.82 | MAP3K5 (0.40) | MAP3K5MYLKTNF | |
| SCHEMBL993194 | 0.79 | MAP3K5 (0.45) | MAP3K5MYLKTNF | |
| SCHEMBL945572 | 0.78 | MAP3K5 (0.68) | MAP3K5MYLKSMN1; SMN2 | |
| SCHEMBL16354007 | 0.78 | NPC1 (0.41) | MAP3K5MYLKTNFSMN1; SMN2 | |
| SCHEMBL943988 | 0.71 | MAP3K5 (0.69) | MAP3K5MYLKSMN1; SMN2 | |
| SCHEMBL952626 | 0.69 | MAP3K5 (0.67) | MAP3K5SMN1; SMN2 | |
| SCHEMBL10220980 | 0.67 | MAP3K5 (0.40) | MAP3K5TNFKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL235196 | 0.67 | MAP3K5 (0.48) | MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |